We anchored In a few different places within the massive harbor.
We tried a spot on the west side of the bay, around 27 5.0056’N 110 52.7315’W. The holding was good here, but the dinghy landing was in stinky mud, and the bobo’s at the boat were enough to drive us nuts.
We really enjoyed the anchorage in front of the marina and downtown. We dropped the hook in about 12ft-10ft. The holding here is great, the marina lets you use the dock to land your dinghy, and you are so close to everything!
We simmered our boat in Guaymas at the Marina Saca ( aka Marina Guaymas/Gaberials yard or the dirt yard) and found the protect anchorages were great when we were decommissioning our boat, and also when we got back, to put her back together.